AN ANALYSIS OF INPUTS TO ON-OFF AMACRINE CELLS IN THE CARP RETINA WITH KYNURENIC ACID

被引：3

作者：

FUJIMOTO, M ^{[1
]}

TOYODA, J ^{[1
]}

机构：

[1] ST MARIANNA MED UNIV, SCH MED, DEPT PHYSIOL, KAWASAKI 216, JAPAN

来源：

NEUROREPORT | 1991年 / 2卷 / 06期

关键词：

CARP RETINA; BIPOLAR CELL; AMACRINE CELL; KYNURENIC ACID; TRANSRETINAL CURRENT;

D O I：

10.1097/00001756-199106000-00004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

AMACRINE cell inputs were studied in the carp retina. Responses to light of bipolar and amacrine cells in off-pathways were suppressed by 0.5 mM kynurenic acid (Kyn), while those in on-pathways were not. In ON-OFF amacrine cells, the sustained potential level during illumination shifted in the depolarizing direction. The depolarizing response elicited in off-center bipolar cells by transretinal current was also suppressed, but those elicited in amacrine cells were not. The results indicated that off-pathways are selectively suppressed by 0.5 mM Kyn at the level of receptor-bipolar synapses and demonstrated that sustained levels of ON-OFF amacrine responses are determined by a balance of inputs from on- and off-center bipolar cells.

引用

页码：317 / 320

页数：4

共 21 条

[1] ROLES OF ASPARTATE AND GLUTAMATE IN SYNAPTIC TRANSMISSION IN RABBIT RETINA .2. INNER PLEXIFORM LAYER [J].

BLOOMFIELD, SA ;

DOWLING, JE .

JOURNAL OF NEUROPHYSIOLOGY, 1985, 53 (03) :714-725

[2] KYNURENIC ACID DISTINGUISHES KAINATE AND QUISQUALATE RECEPTORS IN THE VERTEBRATE RETINA [J].

COLEMAN, PA ;

MASSEY, SC ;

MILLER, RF .

BRAIN RESEARCH, 1986, 381 (01) :172-175

[3] PATHWAYS AND POLARITIES OF SYNAPTIC INTERACTIONS IN THE INNER RETINA OF THE MUDPUPPY .1. SYNAPTIC BLOCKING STUDIES [J].

DACHEUX, RF ;

FRUMKES, TE ;

MILLER, RF .

BRAIN RESEARCH, 1979, 161 (01) :1-12

[4] BIPOLAR CELLS IN THE TURTLE RETINA ARE STRONGLY IMMUNOREACTIVE FOR GLUTAMATE [J].

EHINGER, B ;

OTTERSEN, OP ;

STORMMATHISEN, J ;

DOWLING, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (21) :8321-8325

[5] NEURONAL ARCHITECTURE OF ON AND OFF PATHWAYS TO GANGLION-CELLS IN CARP RETINA [J].

FAMIGLIETTI, EV ;

KANEKO, A ;

TACHIBANA, M .

SCIENCE, 1977, 198 (4323) :1267-1269

[6]

HANKINS MW, 1984, J PHYSIOL-LONDON, V349, pP18

[7] RECEPTIVE FIELD ORGANIZATION OF BIPOLAR AND AMACRINE CELLS IN GOLDFISH RETINA [J].

KANEKO, A .

JOURNAL OF PHYSIOLOGY-LONDON, 1973, 235 (01) :133-153

[8] TRANSIENT CALCIUM CURRENT OF RETINAL BIPOLAR CELLS OF THE MOUSE [J].

KANEKO, A ;

PINTO, LH ;

TACHIBANA, M .

JOURNAL OF PHYSIOLOGY-LONDON, 1989, 410 :613-629

[9]

Kujiraoka T, 1986, Neurosci Res Suppl, V4, pS111, DOI 10.1016/0168-0102(86)90076-3

[10] GAMMA-AMINOBUTYRATE TYPE-B RECEPTOR MODULATION OF L-TYPE CALCIUM-CHANNEL CURRENT AT BIPOLAR CELL TERMINALS IN THE RETINA OF THE TIGER SALAMANDER [J].

MAGUIRE, G ;

MAPLE, B ;

LUKASIEWICZ, P ;

WERBLIN, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (24) :10144-10147

← 1 2 3 →