INVIVO B-11 MRI AND MRS USING (B24H22S2)4- IN THE RAT

被引：12

作者：

KABALKA, GW

CHENG, GQ

BENDEL, P

MICCA, PL

SLATKIN, DN

机构：

[1] Department of Radiology, University of Tennessee Biomedical Imaging Center, Knoxville

[2] Department of Chemistry, University of Tennessee Biomedical Imaging Center, Knoxville

[3] Department of Chemical Physics, Weizmann Institute of Science, Rohovot

[4] Medical Department, Brookhaven National Laboratory, Upton

来源：

MAGNETIC RESONANCE IMAGING | 1991年 / 9卷 / 06期

关键词：

MRI; MRS; BORON; BNCT;

D O I：

10.1016/0730-725X(91)90545-W

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

In vivo boron-11 magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) were performed on a rat that had been infused with a potential boron neutron capture therapy agent, Na4B24H22S2, using methods for detecting nuclei with a short T2 relaxation time. MRI and MRS were also performed on a euthanized rat that had been similarly infused in vivo. Boron-11 spectral intensities decreased in the living rat over a 25-h period. The results demonstrate the capability of MRI and MRS to noninvasively monitor the distribution and excretion of boron agents in vivo.

引用

页码：969 / 973

页数：5

共 12 条

[1]

Abe, Amano, Kitamura, Tateishi, Hatanaka, Boron distribution analysis by alphaautoradiography, J. Nucl. Med., 27, pp. 677-684, (1986)

[2]

Bendel, Davis, Berman, Kabalka, A method for imaging nuclei with short T2 relaxation and its application to boron-11 MR imaging of a BNCT agent in an intact rat, J. Magn. Reson., 88, pp. 369-375, (1990)

[3]

Cory, de Boer, Veeman, Magic angle spinning 1-H NMR imaging of polybutadiene/polystyrene blends, Macromolecules, 22, pp. 1618-1621, (1989)

[4]

Cory, Veeman, Applications of line narrowing to 1-H NMR imaging of solids, J. Magn. Reson., 84, pp. 392-397, (1989)

[5]

Kabalka, Bendel, Davis, Slatkin, Micca, Boron-11 magnetic resonance imaging and spectroscopy: Tools for investigating pharmacokinetics for boron neutron capture therapy, Clinical Aspects of Neutron Capture Therapy, pp. 243-249, (1989)

[6]

Kabalka, Davis, Bendel, Boron-11 MRI and MRS of intact animals infused with a boron neutron capture agent, Magn. Reson. Med., 8, pp. 231-237, (1988)

[7]

Morris, Nuclear Magnetic Resonance Imaging in Medicine and Biology, (1986)

[8]

Richards, Bradshaw, Madden, Aliah-Davis, Batdorf, Imaging of 11B of intact tissues using magnetic resonance gradient echos, Strahlenther. Onkol., 165, pp. 179-183, (1989)

[9]

Slatkin, Micca, Fairchild, Distribution of boron in brain-tumor-bearing rats after infusion of Na4B24H22S2: Implications for neutron capture therapy, Radiology, 157, P, (1985)

[10]

Slatkin, Micca, Forman, Gabel, Wielopolski, Fairchild, Boron uptake in melanoma, cerebrum and blood from Na2B12H11SH and Na4B24H22S2 administered to mice, Biochem. Pharmacol., 35, pp. 1771-1776, (1986)

← 1 2 →