MORPHINE-INDUCED POTENTIATION OF BRAIN-STIMULATION REWARD IS ENHANCED BY MK-801

被引：57

作者：

CARLEZON, WA ^{[1
]}

WISE, RA ^{[1
]}

机构：

[1] CONCORDIA UNIV,CTR STUDIES BEHAV NEUROBIOL,DEPT PSYCHOL,1455 MAISONNEUVE BLVD W,MONTREAL H3G 1M8,QUEBEC,CANADA

来源：

BRAIN RESEARCH | 1993年 / 620卷 / 02期

关键词：

MORPHINE; MK-801; N-METHYL-D-ASPARTATE; BRAIN STIMULATION REWARD; ADDICTION;

D O I：

10.1016/0006-8993(93)90177-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Morphine (2.5 mg/kg, i.p.) and MK-801 (0.05 mg/kg, i.p.) each enhanced the rewarding impact of electrical stimulation of the medial forebrain bundle, causing small but reliable parallel leftward shifts of the functions relating response rate to stimulation frequency. Administration of MK-801 and morphine together caused a profound leftward shift in the functions. This effect was not due to sensitization to either drug, and suggests that disruption of glutamatergic function can potentiate the rewarding impact of opiates.

引用

页码：339 / 342

页数：4

共 20 条

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