PHARMACOLOGY OF DESCENDING NORADRENERGIC SYSTEMS IN RELATION TO MOTOR FUNCTION

The function of descending noradrenergic systems in the spinal ventral horn has not been fully elucidated. We have reviewed our own findings and those of others relating to motor function of these noradrenergic systems. We studied the effects of adrenergic drugs on spinal reflexes, decerebrate rigidity, and noradrenaline release from the spinal cord in rats, and motoneuron activity in spinal cord slices isolated from adult rats. It was shown that the descending noradrenergic systems were facilitatory to the motor system, and that cur-antagonistic action at the spinal cord and alpha(2)-agonistic action at the brainstem inhibited spinal motor activity by blocking spinal alpha(1)-receptors and by reducing the release of noradrenaline in the spinal cord, respectively.