A BIDIRECTIONAL YAC WALK FROM THE NORRIE DISEASE (NDP) LOCUS

被引：4

作者：

BLACK, GCM

COLEMAN, MP

CHEN, ZY

NEMETH, AH

DAVIES, KE

CRAIG, IW

机构：

[1] DEPT BIOCHEM,GENET LAB,OXFORD,ENGLAND

[2] JOHN RADCLIFFE HOSP,INST MOLEC MED,OXFORD OX3 9DU,ENGLAND

来源：

GENOMICS | 1995年 / 25卷 / 03期

关键词：

D O I：

10.1016/0888-7543(95)80006-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The region of Xp between DXS7 and the centromere contains the gene for Norrie disease in addition to the genes for several other ophthalmic disorders, A 650-kb YAC containing the loci MAOA, MAOB, and NDP has been used as the starting point for a bidirectional chromosomal walk. A contig of 16 YACs covering between 2 and 3 Mb has been developed in which the following markers/genes are located (in physical order): Xpter - DXS1201 (256ze5) - DXS6668 - DXS228 - DXS77 - DXS7 - MAOA - MAOB - FR12 (pseudogene) - NDP - DXS6670 - RRM2P3 - DXS6671 - DXS742 - Xcen. Seven new STSs are described both for end clones and for internal Alu PCR products from the contig, The contig contains the breakpoint of the t75-2ma-1b (t75) translocation, close to the 5' end of the MAOB gene. (C) 1995 Academic Press, Inc.

引用

页码：644 / 649

页数：6

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