MECHANISM OF CYCLOHEXIMIDE INHIBITION OF PROTEIN SYNTHESIS IN RABBIT RETICULOCYTES

被引：145

作者：

MCKEEHAN, W

HARDESTY, B

机构：

[1] Clayton Foundation Biochemical Institute Department, Chemistry The University of Texas, Austin

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 36卷 / 04期

关键词：

D O I：

10.1016/0006-291X(69)90351-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cycloheximide blocks the movement of peptidyl-tRNA from acceptor (aminoacyl) site to the donor (peptidyl) site on reticulocyte ribosomes. This translocation reaction is dependent upon the transfer enzyme, TF-II, and GTP hydrolysis. Cycloheximide has no effect on the ribosome dependent GTPase activity of TF-II or on the peptidyl transferase reaction by which peptides on tRNA in the donor ribosomal site are transferred to an amino acid on tRNA in the acceptor site. © 1969.

引用

页码：625 / &

共 9 条

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