CYNOMOLGUS MONKEY MODEL FOR EXPERIMENTAL Q-FEVER INFECTION

被引：34

作者：

GONDER, JC ^{[1
]}

KISHIMOTO, RA ^{[1
]}

KASTELLO, MD ^{[1
]}

PEDERSEN, CE ^{[1
]}

LARSON, EW ^{[1
]}

机构：

[1] USA, MED RES INST INFECT DIS, DIV RICKETTSIOL, FREDERICK, MD 21701 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1979年 / 139卷 / 02期

关键词：

D O I：

10.1093/infdis/139.2.191

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A subhuman primate model was developed for study of the pathogenesis of infection with Coxiella burnetii. Cynomolgus monkeys (Macaca fascicularis) that were exposed to 105 mouse median infectious i.p. doses of C. burnetii in a small-particle aerosol developed clinical signs of illness and pathologic changes characteristic of Q fever infection in humans. All monkeys had radiologic evidence of pneumonia by day 9. Antibodies to C. burnetii were detectable by the indirect fluorescent antibody test by day 7. The cynomolgus monkey may be a suitable model for study of the pathogenesis of Q fever infection and may prove valuable in the evaluation of C. burnetii vaccines.

引用

页码：191 / 196

页数：6

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