PLATINUM(II) COMPLEXES GENERATE FRAME-SHIFT MUTATIONS IN TEST STRAINS OF SALMONELLA-TYPHIMURIUM

被引:46
作者
ANDERSEN, KS
机构
[1] Institute of Life Sciences and Chemistry, Roskilde University, DK 4000 Roskilde
来源
MUTATION RESEARCH | 1979年 / 67卷 / 03期
关键词
D O I
10.1016/0165-1218(79)90014-4
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
cis-Diamminodichloroplatinum(II) (cis-PDD) and diaquoethylenediamine-platinum(II) induce histidine revertants in Salmonella typhimurium strains TA98 (frame-shift mutation) and TA100 (base-pair substitution mutation). A linear dose-response relationship is found with cis-PDD acting on TA98 and TA100. Salmonella typhimurium strains TA1535, TA1537 and TA1538 are not sensitive to the mutagenic action of cis-PDD. All 5 strains are sensitive to the toxic effect of cis-PDD. Platinum(II) complexes induce mutations (frame-shift or base-pair substitution) only in strains carrying the R-factor plasmid. © 1979.
引用
收藏
页码:209 / 214
页数:6
相关论文
共 12 条