PLATINUM(II) COMPLEXES GENERATE FRAME-SHIFT MUTATIONS IN TEST STRAINS OF SALMONELLA-TYPHIMURIUM

cis-Diamminodichloroplatinum(II) (cis-PDD) and diaquoethylenediamine-platinum(II) induce histidine revertants in Salmonella typhimurium strains TA98 (frame-shift mutation) and TA100 (base-pair substitution mutation). A linear dose-response relationship is found with cis-PDD acting on TA98 and TA100. Salmonella typhimurium strains TA1535, TA1537 and TA1538 are not sensitive to the mutagenic action of cis-PDD. All 5 strains are sensitive to the toxic effect of cis-PDD. Platinum(II) complexes induce mutations (frame-shift or base-pair substitution) only in strains carrying the R-factor plasmid. © 1979.