PRECAUTIONARY NOTE REGARDING DERIVATIZATION OF SECONDARY-AMINES WITH DIALKYLACETALS OF FORMAMIDE OTHER THAN THE DIETHYL DERIVATIVE

被引：5

作者：

NARASIMHACHARI, N

FRIEDEL, RO

机构：

[1] Department of Psychiatry, Medical College of Virginia, Richmond, Virginia

来源：

ANALYTICAL LETTERS PART A-CHEMICAL ANALYSIS | 1979年 / 12卷 / 12期

关键词：

diethyl acetal; dimethyl acetal; dipropyl acetal; DMF; N-ethylation;

D O I：

10.1080/00032717908067920

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We have extended our earlier work on alkylation of secondary amino compounds with dimethylformamide diethyl acetal to other alkyl acetals, such as dimethyl and dipropyl acetal. All the alkylating DMT-dialkyl acetal reagents tested gave only N-ethyl derivatives of, the secondary amines. The reagent purity was tested by preparing the esters of carboxylic acids, where the appropriate alkyl (methyl or propyl) ester is obtained. It is concluded that all dimethylformamide dialkyl acetals yield a single N-ethyl derivative of secondary amine. The reaction mechanism is not understood. © 1979 Taylor & Francis Group. All rights reserved.

引用

页码：1293 / 1304

页数：12