ENDOMETRIAL PATTERNS DURING DANAZOL AND CYPROTERONE-ACETATE TREATMENT FOR ENDOMETRIOSIS - STRUCTURAL AND ULTRASTRUCTURAL-STUDY

被引：3

作者：

MARCHINI, M ^{[1
]}

FEDELE, L ^{[1
]}

BIANCHI, S ^{[1
]}

ARCAINI, L ^{[1
]}

BRIOSCHI, D ^{[1
]}

DINOLA, G ^{[1
]}

机构：

[1] UNIV MILAN, DEPT OBSTET & GYNECOL 1, VIA COMMENDA 12, I-20122 MILAN, ITALY

来源：

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 1991年 / 40卷 / 02期

关键词：

ENDOMETRIUM; DANAZOL; CYPROTERONE ACETATE;

D O I：

10.1016/0028-2243(91)90105-T

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We studied the endometrial structure and ultrastructure in serial biopsies from 16 patients with endometriosis treated with danazol (n = 9) or the combination cyproterone acetate plus ethinyl estradiol (n = 7) for 6 months. Biopsies were performed before and at 3 and 6 months of treatment. The material obtained was studied by light (LM), scanning (SEM) and transmission electron microscopy (TEM). A morphometric analysis was performed evaluating three morphometric and three stereologic indices. The results indicate that danazol had a progestational effect on endometrial glands and stroma, associated with a marked hypotrophy of the mucosa. The cyproterone acetate/ethinyl estradiol combination induced progressive atrophy of the endometrium with an increase in the stromal component and a reduction of glandular tissue.

引用

页码：137 / 143

页数：7

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