INOSITOL 1,4,5-TRISPHOSPHATE ACTIVATES 2 TYPES OF CA-2+-PERMEABLE CHANNELS IN HUMAN CARCINOMA-CELLS

被引：39

作者：

MOZHAYEVA, GN

NAUMOV, AP

KURYSHEV, YA

机构：

[1] Institute of Cytology, Academy of Sciences, the USSR, Leningrad

来源：

FEBS LETTERS | 1990年 / 277卷 / 1-2期

关键词：

PATCH CLAMP; CARCINOMA CELL; CALCIUM CHANNEL; EPIDERMAL GROWTH FACTOR; INOSITOL 1,4,5-TRISPHOSPHATE;

D O I：

10.1016/0014-5793(90)80853-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ca2+-permeable channels in human carcinoma A431 cells were studied using the patch clamp technique. We have found two types of Ca2+-permeable channels which are activated by inositol 1,4,5-trisphosphate (IP3) applied to the intracellular side of the plasma membrane. Unitary conductances of these channels are 3.7 and 13 pS (105 mM Ca2+ in recording pipette, 30-33-degrees-C). From the extracellular side of the membrane the channels are activated by EGF. It is assumed that extracellular agonists open both channel types by stimulating the release of IP3 from the membrane.

引用

页码：233 / 234

页数：2

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