FLOW-INDUCED PROSTACYCLIN PRODUCTION IS MEDIATED BY A PERTUSSIS TOXIN-SENSITIVE G-PROTEIN

被引：70

作者：

BERTHIAUME, F ^{[1
]}

FRANGOS, JA ^{[1
]}

机构：

[1] PENN STATE UNIV,DEPT CHEM ENGN,150 FENSKE BLDG,UNIV PK,PA 16802

来源：

FEBS LETTERS | 1992年 / 308卷 / 03期

关键词：

PROSTACYCLIN; G-PROTEIN; PERTUSSIS TOXIN; SHEAR STRESS; HISTAMINE; ENDOTHELIAL CELL;

D O I：

10.1016/0014-5793(92)81292-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fluid flow and several other agonists induce prostacyclin (PGI2) production in endothelial cells. G proteins mediate the response of a large number of hormones such as histamine, but the transduction pathway of the flow signal is unclear. We found that GDP-beta-S and pertussis toxin inhibited flow-induced prostacyclin production in human umbilical vein endothelial cells. In addition, flow potentiated the histamine-induced production of PGI2. This suggests that flow stimulates prostacyclin production via a pertussis toxin-sensitive G protein and modulates the stimulus-response coupling of other agonists.

引用

页码：277 / 279

页数：3

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