DIFFERENT BRAIN AREAS MEDIATE ANALGESIC AND EPILEPTIC PROPERTIES OF ENKEPHALIN

被引：159

作者：

FRENK, H ^{[1
]}

MCCARTY, BC ^{[1
]}

LIEBESKIND, JC ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,DEPT PSYCHOL,LOS ANGELES,CA 90024

来源：

SCIENCE | 1978年 / 200卷 / 4339期

关键词：

D O I：

10.1126/science.204998

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Single injections of 120 micrograms of methionine-enkephalin were made into various midbrain and forebrain structures in the rat. Analgesia was observed after injections into or near the ventral, caudal midbrain periaqueductal gray matter. Seizures and other pathological electroencephalogram (EEG) changes were seen with injections into or near the forebrain dorsomedial nucleus of the thalamus. No animals with midbrain injection sites showed EEG changes, and none with forebrain injection sites were analgesic. These data, taken together with other lines of evidence, suggest that enkephalin-induced analgesia and enkephalin-induced seizures are mediated by opiate receptors that are located in different brain areas and that are pharmacologically different. Copyright © 1978 AAAS.

引用

页码：335 / 337

页数：3

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