AN EFFICIENT CHEMOENZYMATIC APPROACH TO (+)-MEROQUINENE

被引：18

作者：

DANIELI, B

LESMA, G

MAURO, M

PALMISANO, G

PASSARELLA, D

机构：

[1] Dipartimento di Chimica Organica e Industriale, Universita' degli Studi di Milano, Centro CNR per lo Studio delie Sostanze Organiche Naturali, 20133 Milano

来源：

TETRAHEDRON-ASYMMETRY | 1990年 / 1卷 / 11期

关键词：

D O I：

10.1016/S0957-4166(00)80445-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Meroquinene (+)-1 was prepared in an efficient and stereocontrolled fashion from (1R-2S)-4-cyclohexene dimethanol monoacetate (-)-8. Key steps are the enzyme-catalyzed hydrolysis of the available diacetate 5 to (-)-8 and of the intermediate diester 17 to hemiester 18, which allow the stereo- and regiocontrolled elaboration of the vicinal vinyl and carboxymethyl groups. © 1990.

引用

页码：793 / 800

页数：8

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