INHIBITION OF FOLLICLE-STIMULATING-HORMONE SECRETION FROM GONADOTROPH ADENOMAS BY REPETITIVE ADMINISTRATION OF A GONADOTROPIN-RELEASING-HORMONE ANTAGONIST

被引:24
作者
DANESHDOOST, L
PAVLOU, SN
MOLITCH, ME
GENNARELLI, TA
SAVINO, PJ
SERGOTT, RC
BOSLEY, TM
RIVER, JE
VALE, WW
SNYDER, PJ
机构
[1] UNIV PENN, SCH MED, DEPT MED, ENDOCRINOL SECT, PHILADELPHIA, PA 19104 USA
[2] UNIV PENN, SCH MED, DIV NEUROL SURG, PHILADELPHIA, PA 19104 USA
[3] VANDERBILT UNIV, MED CTR,SCH MED,DEPT INTERNAL MED,DIV ENDOCRINOL, NASHVILLE, TN 37232 USA
[4] NORTHWESTERN UNIV, SCH MED, CTR ENDOCRINOL METAB & NUTR, CHICAGO, IL 60611 USA
[5] WILLS EYE HOSP & RES INST, NEUROOPHTHALMOL SERV, PHILADELPHIA, PA 19107 USA
[6] SALK INST BIOL STUDIES, PEPTIDE BIOL LAB, LA JOLLA, CA 92138 USA
关键词
D O I
10.1210/jcem-71-1-92
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
As a preliminary step in searching for a pharmacological treatment for gonadotroph adenomas, we administered the GnRH antagonist analog Nal-Glu GnRH to five patients, four men and a woman, with FSH-secreting gonadotroph adenomas in order to determine its effect on FSH secretion. Administration of a single 10-mg dose of Nal-Glu GnRH to four of the patients produced a significant decrease in the serum FSH concentration in two patients and returned the FSH level t o normal in only one. Administration of 5 mg Nal-Glu every 12h for 7 days, however, produced a significant (P < 0.001) decrease, and to within the normal range, in four of the five patients (mean ± SEM, 32.7 ± 5.6 IU/L during the 3 days before treatment and 9.8 ± 1.4 IU/L during the last 3 days of treatment). Also, in response to the 7-day treatment, LH fell significantly in all five patients, a-subunit fell in three, and testosterone fell in all four men. Administration for 6 weeks of the GnRH agonist analog leuprolide did not decrease the serum FSH concentration of one of the patients whose serum FSH did decrease in response to Nal-Glu GnRH. We conclude that repetitive administration of Nal-Glu GnRH may often inhibit FSH secretion by gonadotroph adenomas and that FSH secretion by gonadotroph adenomas may be dependent on endogenous GnRH secretion. © 1990 by The Endocrine Society.
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页码:92 / 97
页数:6
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