PRESYNAPTIC GABA AUTORECEPTORS ON GABAERGIC NERVE-ENDINGS OF THE RAT SUBSTANTIA NIGRA

被引：101

作者：

ARBILLA, S

KAMAL, L

LANGER, SZ

机构：

[1] Biology Department Synthélabo (L.E.R.S.), 75013 Paris, 58, rue de la Glacière

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 57卷 / 2-3期

关键词：

GABA; Muscimol; Neurotransmission; Picrotoxin; Presynaptic receptors; Rat occipital cortex; Rat substantia nigra;

D O I：

10.1016/0014-2999(79)90367-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The release of 3H-GABA evoked by exposure to 30 mM potassium during 1 min was found to be calcium independent in the rat occipital cortex and calcium dependent in the substantia nigra. Exposure to either muscimol 1 μM or GABA 1 μM inhibited the potassium-evoked release release of 3H-GABA from the substantia nigra but not from the occipital cortex. The inhibitory effect of muscimol 1 μM on the pitassium-evoked release of 3H-GABA from the substantia nigra was significantly antagonized by picrotoxin 10 μM. Exposure to either 10 or 100 μM pricotoxin alone did not affect the potassium-evoked release of 3H-GABA. These results are compatible with the presence of a negative feedback mechanism in gabaergic nerve terminals of the rat substantia nigra which is mediated by presynaptic GABA autoreceptors. In addition, these results emphasize the importance of the calcium-dependent dependent nature of the release of the neurotransmitter for demonstrating the modulation of transmitter release through presynaptic receptors. © 1979.

引用

页码：211 / 217

页数：7

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