PHARMACOKINETIC ASPECTS OF THE SUBLINGUAL ADMINISTRATION OF VINCAMINE

被引：5

作者：

AIACHE, JM

DELATTE, MC

LEBLANC, PP

KANTELIP, JP

STEIMER, JL

机构：

[1] INSERM,U195,F-63001 CLERMONT FERRAND,FRANCE

[2] STUDY & RES CTR MED STAT & INFORMAT PROC,F-94008 CRETEIL,FRANCE

[3] UNIV PARIS 06,DEPT BIOPHYS & BIOMATH,INSERM,U194,F-75634 PARIS 13,FRANCE

[4] FAC MED CLERMONT,DEPT PHARMACOL,F-63001 CLERMONT FERRAND,FRANCE

[5] UNIV LAVAL,SCH PHARM,DEPT PHARMACOKINET,QUEBEC CITY G1K 7P4,QUEBEC,CANADA

来源：

BIOPHARMACEUTICS & DRUG DISPOSITION | 1990年 / 11卷 / 04期

关键词：

Sublingual absorption; Sublingual pharmacokinetics; Vincamine;

D O I：

10.1002/bdd.2510110402

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The sublingual absorption of vincamine used as tracer occurs in two successive absorption steps: true sublingual absorption and absorption in the gastrointestinal tract of the drug dissolved in the saliva and not absorbed through the buccal mucosa. This is confirmed by a pharmacokinetic study and simulation. These two successive absorptions can explain the increase in the amounts of drug absorbed. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：279 / 309

页数：31

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