THE INCIDENCE OF ABNORMAL MORPHOLOGY AND NUCLEOCYTOPLASMIC RATIOS IN 2-DAY, 3-DAY AND 5-DAY HUMAN PREEMBRYOS

被引：85

作者：

WINSTON, NJ

BRAUDE, PR

PICKERING, SJ

GEORGE, MA

CANT, A

CURRIE, J

JOHNSON, MH

机构：

[1] Embryo and Gamete Research Group, Departments of Anatomy and Obstetrics and Gynaecology, University of Cambridge

来源：

HUMAN REPRODUCTION | 1991年 / 6卷 / 01期

基金：

英国医学研究理事会;

关键词：

HUMAN BLASTOCYST; PREEMBRYO; NUCLEOCYTOPLASMIC RATIO; PREIMPLANTATION DEVELOPMENT;

D O I：

10.1093/oxfordjournals.humrep.a137253

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Human cleaving pre-embryos at 2 and 3 days and cavitated pre-embryos at 5 days post-insemination have been examined for cell number and the incidence of mononucleated cells. At least 60% of polynucleate or anucleate cells have been detected at all these stages and regardless of morphological grading at day 2. It is concluded that even by the time at which pre-embryo replacement would occur therapeutically, the majority of pre-embryos are unlikely to have full developmental potential. The possible origins of the abnormalities of nucleocytoplasmic ratios are discussed.

引用

页码：17 / 24

页数：8

共 48 条

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