PHARMACOKINETIC MODELING OF PLASMA AND CEREBROSPINAL-FLUID METHOTREXATE AFTER HIGH-DOSE INTRAVENOUS-INFUSION IN CHILDREN

被引：14

作者：

CHATELUT, E

ROCHE, H

PLUSQUELLEC, Y

PEYRILLE, F

DEBIASI, J

PUJOL, A

CANAL, P

HOUIN, G

机构：

[1] CTR INTERDISCIPLINAIRE ETUDES PHARMACOCINET TOULOUSE,TOULOUSE,FRANCE

[2] UNIV TOULOUSE 3,UFR MATH,F-31062 TOULOUSE,FRANCE

[3] CTR CLAUDIUS REGAUD,UNITE PHARMACOL & PHARMACOCINET CLIN,F-31052 TOULOUSE,FRANCE

[4] CHR PURPAN,UNITE PHARMACOCINET,TOULOUSE,FRANCE

[5] CHR PURPAN,SERV PEDIAT,TOULOUSE,FRANCE

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1991年 / 80卷 / 08期

关键词：

D O I：

10.1002/jps.2600800804

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A pharmacokinetic study was performed in plasma and cerebrospinal fluid (CSF) of patients suffering from brain tumors to describe the disposition of methotrexate. An open three-compartment model was developed to fit together the data obtained in plasma and CSF. The pharmacokinetic parameters obtained by the model agreed with those obtained with classical analysis and the fitting correctly depicted the plasma and CSF concentration decays. According to the results, such a model could be applied to other anticancer drugs.

引用

页码：730 / 734

页数：5

共 19 条

[1] HIGH-DOSE METHOTREXATE - A CRITICAL REAPPRAISAL
ACKLAND, SP
SCHILSKY, RL
[J]. JOURNAL OF CLINICAL ONCOLOGY, 1987, 5 (12) : 2017 - 2031
[2] BLEYER WA, 1977, CANCER TREAT REP, V61, P703
[3] BODE U, 1980, CANCER RES, V40, P2184
[4] BORSI JD, 1987, CANCER, V60, P5, DOI 10.1002/1097-0142(19870701)60:1<5::AID-CNCR2820600103>3.0.CO
[5] 2-D
[6] BREITHAUPT H, 1982, CANCER TREAT REP, V66, P1733
[7] A PHARMACOKINETIC MODEL FOR INTRAPERITONEAL ADMINISTRATION OF DRUGS - APPLICATION TO TENIPOSIDE IN HUMANS
CANAL, P
PLUSQUELLEC, Y
CHATELUT, E
BUGAT, R
DEBIASI, J
HOUIN, G
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1989, 78 (05) : 389 - 392
[8] METHOTREXATE CEREBROSPINAL-FLUID AND SERUM CONCENTRATIONS AFTER INTERMEDIATE-DOSE METHOTREXATE INFUSION
EVANS, WE
HUTSON, PR
STEWART, CF
CAIRNES, DA
BOWMAN, WP
RIVERA, G
CROM, WR
[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1983, 33 (03) : 301 - 307
[9] CLINICAL PHARMACODYNAMICS OF HIGH-DOSE METHOTREXATE IN ACUTE LYMPHOCYTIC-LEUKEMIA - IDENTIFICATION OF A RELATION BETWEEN CONCENTRATION AND EFFECT
EVANS, WE
CROM, WR
ABROMOWITCH, M
DODGE, R
LOOK, AT
BOWMAN, WP
GEORGE, SL
PUI, CH
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1986, 314 (08) : 471 - 477
[10] 7-HYDROXYMETHOTREXATE CYTOTOXICITY AND SELECTIVITY IN A HUMAN BURKITTS-LYMPHOMA CELL-LINE VERSUS HUMAN GRANULOCYTIC PROGENITOR CELLS - RESCUE BY FOLINIC ACID AND NUCLEOSIDES
FABRE, I
FABRE, G
CANO, JP
[J]. EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1986, 22 (10): : 1247 - 1254

← 1 2 →