GLUCOCORTICOIDS INHIBIT TNF-ALPHA-INDUCED CYTOSOLIC PHOSPHOLIPASE-A2 ACTIVITY

被引：60

作者：

GOPPELTSTRUEBE, M ^{[1
]}

REHFELDT, W ^{[1
]}

机构：

[1] MED SCH HANNOVER, INST MOLEC PHARMACOL, HANNOVER, GERMANY

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1127卷 / 02期

关键词：

CYTOSOLIC PHOSPHOLIPASE-A2; GLUCOCORTICOID; TUMOR NECROSIS FACTOR; PHOSPHOLIPASE-A2;

D O I：

10.1016/0005-2760(92)90273-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cytosolic phospholipase A2 (PLA2) was characterized in the human epithelial carcinoma cell line HEp-2 by its apparent molecular mass (about 80 kDa); its in vitro activation by micromolar concentrations of calcium; and its calcium-dependent association with cellular membranes. The activity of this enzyme was induced by an overnight incubation with tumor necrosis factor-alpha (TNF-alpha). Glucocorticoids only moderately reduced PLA2 activity in control cells, but completely inhibited the TNF-alpha-induced increase in the activity of the high-molecular-weight cytosolic PLA2.

引用

页码：163 / 167

页数：5

共 28 条

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