A TIGHT CLUSTER OF 5 UNRELATED HUMAN GENES ON CHROMOSOME-16Q22.1

被引：75

作者：

LARSEN, F ^{[1
]}

SOLHEIM, J ^{[1
]}

KRISTENSEN, T ^{[1
]}

KOLSTO, AB ^{[1
]}

PRYDZ, H ^{[1
]}

机构：

[1] UNIV OLSO, BIOTECHNOL CTR OSLO, POB 1125, N-0316 OSLO, NORWAY

来源：

HUMAN MOLECULAR GENETICS | 1993年 / 2卷 / 10期

关键词：

D O I：

10.1093/hmg/2.10.1589

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A locus on human chromosome 16q22.1 contains at least five tightly clustered genes which are unrelated by sequence homology and apparently unrelated by function. The genes for a putative proteasome subunit (MECL1), a chymotrypsin-like protease (CTRL), a protein serine kinase (PSKH1), the previously cloned lecithin:cholesterol acyl transferase (LCAT) and a protein of unknown function are found within 40 kb of genomic DNA. Exons from the former four genes are located within a 12 kb region including a CpG island associated with the putative proteasome gene. Three of the genes are widely expressed, whereas the genes for the protease and LCAT are highly tissue specific. The distance between the transcriptional units of the gene upstream of LCAT and LCAT is only 199 bp. Alternative polyadenylation of the protease transcripts creates a transcription unit which overlaps with the oppositely oriented kinase gene. The selective advantage of this unusual gene clustering may involve transcriptional interference(s) and coregulatory events not yet understood. Given the current estimate of about 100 000 genes in the human genome, our findings support the notion that genes are not evenly distributed.

引用

页码：1589 / 1595

页数：7

共 59 条

[1] AUTOMATED DNA SEQUENCING - ULTRASENSITIVE DETECTION OF FLUORESCENT BANDS DURING ELECTROPHORESIS [J].

ANSORGE, W ;

SPROAT, B ;

STEGEMANN, J ;

SCHWAGER, C ;

ZENKE, M .

NUCLEIC ACIDS RESEARCH, 1987, 15 (11) :4593-4602

[2] THE STRUCTURAL GENE FOR LECITHIN - CHOLESTEROL ACYL TRANSFERASE (LCAT) MAPS TO 16Q22 [J].

AZOULAY, M ;

HENRY, I ;

TATA, F ;

WEIL, D ;

GRZESCHIK, KH ;

CHAVES, ME ;

MCINTYRE, N ;

WILLIAMSON, R ;

HUMPHRIES, SE ;

JUNIEN, C .

ANNALS OF HUMAN GENETICS, 1987, 51 :129-136

[3] STRUCTURE AND VARIABILITY OF RECENTLY INSERTED ALU FAMILY MEMBERS [J].

BATZER, MA ;

KILROY, GE ;

RICHARD, PE ;

SHAIKH, TH ;

DESSELLE, TD ;

HOPPENS, CL ;

DEININGER, PL .

NUCLEIC ACIDS RESEARCH, 1990, 18 (23) :6793-6798

[4] MAMMALIAN CHROMOSOME-BANDING - AN EXPRESSION OF GENOME ORGANIZATION [J].

BICKMORE, WA ;

SUMNER, AT .

TRENDS IN GENETICS, 1989, 5 (05) :144-148

[5] CPG ISLANDS AS GENE MARKERS IN THE VERTEBRATE NUCLEUS [J].

BIRD, AP .

TRENDS IN GENETICS, 1987, 3 (12) :342-347

[6] GENE NUMBERS GAME [J].

BISHOP, JO .

CELL, 1974, 2 (02) :81-86

[7]

BODMER WF, 1981, AM J HUM GENET, V33, P664

[8]

BYAS P, 1992, CELL, V69, P781

[9] CDNA SEQUENCE AND GENOMIC STRUCTURE OF EV12B, A GENE LYING WITHIN AN INTRON OF THE NEUROFIBROMATOSIS TYPE-1 GENE [J].

CAWTHON, RM ;

ANDERSEN, LB ;

BUCHBERG, AM ;

XU, GF ;

OCONNELL, P ;

VISKOCHIL, D ;

WEISS, RB ;

WALLACE, MR ;

MARCHUK, DA ;

CULVER, M ;

STEVENS, J ;

JENKINS, NA ;

COPELAND, NG ;

COLLINS, FS ;

WHITE, R .

GENOMICS, 1991, 9 (03) :446-460

[10] CHROMOSOMAL LOOP ANCHORAGE OF THE KAPPA IMMUNOGLOBULIN GENE OCCURS NEXT TO THE ENHANCER IN A REGION CONTAINING TOPOISOMERASE-II SITES [J].

COCKERILL, PN ;

GARRARD, WT .

CELL, 1986, 44 (02) :273-282

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