ATTENUATED VARICELLA VIRUS-VACCINE IN CHILDREN WITH RENAL-TRANSPLANTS

被引：122

作者：

ZAMORA, I

SIMON, JM

DASILVA, ME

PIQUERAS, AI

机构：

[1] Paediatric Nephrology Unit, Hospital Infantil La Fe, Valencia

来源：

PEDIATRIC NEPHROLOGY | 1994年 / 8卷 / 02期

关键词：

VARICELLA; VACCINE; RENAL TRANSPLANT;

D O I：

10.1007/BF00865476

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The long-term efficacy of varicella vaccine was studied in 34 children aged 2-18 years who were either on chronic dialysis (n = 17) or were renal transplant recipients (n = 17). Live attenuated virus (OKA line) was inoculated in a single 0.5-ml subcutaneous dose, without modification of the immunosuppressive therapy protocol for renal transplant recipients. The majority of children (85%) developed antibodies within the first 6 months, with IgG titres (enzyme-linked immunosorbent assay) greater than 1:40 (geometric mean 1:640). Of those children who were followed for longer than 2 years, 76% maintained their antibody titres. Reactions to the vaccine were minimal and the immunological protection was effective. Only 3 children developed a mild form of varicella in the post-vaccination period. We consider that seronegative children who are candidates for renal transplantation must be protected against varicella by attenuated varicella vaccination. When vaccination is performed after transplantation, no modification of immunosuppressive therapy is needed.

引用

页码：190 / 192

页数：3

共 20 条

[1] Feldman S., Hughes T., Daniel C.B., Varicella in children with cancer: seventy-seven cases, Pediatrics, 56, pp. 388-397, (1975)
[2] Lobut J.P., Michon J., Lemerle S., Bouvet E., Foulon G., Fréquence de la varicelle chez lénfant immunodérpimé, Arch Fr Pediatr, 46, pp. 77-80, (1989)
[3] Balfour H.H., Intravenous acyclovir therapy for varicella in immunocompromised children, J Pediatr, 104, pp. 134-136, (1984)
[4] Whitley R., Hilty M., Haynes R., Bryson Y., Connor J.D., Soong S.J., Alford C.A., Vidarabine therapy of varicella in immunosuppressed patients, J Pediatr, 101, pp. 125-131, (1982)
[5] Schulman S.L., Deforest A., Fisher M.C., Kaiser B., Polinsky M., Baluarte H.J., Varicella: effect of the disease and therapy on pediatric renal transplant recipients, Am J Kidney Dis, 19, (1992)
[6] Le Guen E., Deminiere C., Larue J.R., Postec E., Morel D., Aparicio M., Potaux L., Fatal varicella or Reye's syndrome: an unusual cause of death in a renal graft recipient, Nephrol Dial Transplant, 7, pp. 158-160, (1992)
[7] Morgan E.R., Smalley L.A., Varicella in immunocompromised children. Incidence of abdominal pain and organ involvement, Am J Dis Child, 137, pp. 883-885, (1983)
[8] Bradley J.R., Wreghitt T.G., Evans D.B., Chickenpox in adult renal transplant recipients, Nephrol Dial Transplant, 1, pp. 242-245, (1987)
[9] Lynfield R., Herrin J.T., Rubin R.H., Varicella in pediatric renal transplant recipients, Pediatrics, 90, pp. 216-220, (1992)
[10] Schroter G.P.J., Fatal varicella with liver necrosis after kidney transplantation, Clin Transplant, 6, pp. 388-390, (1992)

← 1 2 →