REFRACTORY CYTOPENIA WITH T(1-7), +8 ABNORMALITY AND DYSPLASTIC EOSINOPHILS SHOWING INTRANUCLEAR CHARCOT-LEYDEN CRYSTALS - A FLUORESCENCE IN-SITU HYBRIDIZATION STUDY

被引：25

作者：

MA, SK ^{[1
]}

WONG, KF ^{[1
]}

CHAN, JKC ^{[1
]}

KWONG, YL ^{[1
]}

机构：

[1] QUEEN MARY HOSP, DEPT MED, HONG KONG, HONG KONG

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1995年 / 90卷 / 01期

关键词：

MYELODYSPLASTIC SYNDROME; DYSPLASTIC EOSINOPHILS; CHARCOT-LEYDEN CRYSTAL; T(1-7) AND TRISOMY 8; FISH;

D O I：

10.1111/j.1365-2141.1995.tb03405.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A case of refractory cytopenia and marrow eosinophilia showing t(1;7) translocation and concomitant trisomy 8 is reported. The eosinophils were dysplastic, and showed the unique feature of intranuclear Charcot-Leyden crystal formation, giving rise to a 'lip-like' appearance, We speculate that this unusual cytologic feature resulted from abnormal precipitation of Charcot-Leyden crystal protein in the eosinophils. By fluorescence in situ hybridization using a chromosome 8 specific alpha-satellite probe, the abnormal eosinophils were shown to have derived from the abnormal clone. We postulate that the dysplastic clone might have retained a differentiation potential and be responsive to normal haemopoietic stimuli.

引用

页码：216 / 218

页数：3

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