APOPTOSIS AND P53 PROTEIN EXPRESSION IN HUMAN HEPATOMA-CELLS INDUCED BY ETOPOSIDE, MITOMYCIN-C AND THAPSIGARGIN

被引：3

作者：

KANEKO, Y

TSUKAMOTO, A

机构：

[1] First Department of Medicine, University of Tokyo, Faculty of Medicine, Bunkyo-ku, Tokyo, 113

来源：

INTERNATIONAL HEPATOLOGY COMMUNICATIONS | 1994年 / 2卷 / 06期

关键词：

CENTROMERE ANTIBODY; ANTICANCER DRUG; THAPSIGARGIN; TUMOR SUPPRESSOR GENE;

D O I：

10.1016/0928-4346(94)90024-8

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We found that the anti-cancer drugs of mitomycin C and etoposide will induce chromatin decondensation in human PLC/PRF/5 hepatoma cells, while the tumor promoter thapsigargin instead induces chromatin condensation. Both of these changes are subsequently followed by internudeosomal DNA cleavage and cell death characteristic to apoptosis. The p53 protein, which is known to induce apoptosis, increased in the anti-cancer drug-treated cells but not in thapsigargin-treated cells, thereby strongly suggesting that p53-dependent and -independent pathways linked to apoptosis exist in this hepatoma cell line.

引用

页码：305 / 309

页数：5

共 16 条

[1]

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