ACCELERATION OF A PHOSPHATE DIESTER TRANSESTERIFICATION REACTION BY BIS(ALKYLGUANIDINIUM) RECEPTORS CONTAINING AN APPENDED GENERAL BASE

被引：91

作者：

JUBIAN, V ^{[1
]}

VERONESE, A ^{[1
]}

DIXON, RP ^{[1
]}

HAMILTON, AD ^{[1
]}

机构：

[1] UNIV PITTSBURGH,DEPT CHEM,PITTSBURGH,PA 15217

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 11期

关键词：

ENZYME MIMICS; GUANIDINES; TRANSESTERIFICATIONS;

D O I：

10.1002/anie.199512371

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rate enhancements up to 290‐fold are possible for the transesterification of 2‐hydroxypropyl‐p‐nitrophenylphosphate when bis(guanidinium) catalysts bearing basic groups are added. The combination of the appended base and the electrostatic complementarity of substrate and receptor (see complex 1) make the guanidinium compounds efficient enzyme mimics. These types of compounds may have therapeutic applications as artificial nucleases. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

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页码：1237 / 1239

页数：3

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