NEONATAL ALLOIMMUNE THROMBOCYTOPENIA IN TAIWAN DUE TO AN ANTIBODY AGAINST A LABILE COMPONENT OF HPA-3A (BAK(A))

被引：29

作者：

LIN, M

SHIEH, SH

LIANG, DC

YANG, TF

SHIBATA, Y

机构：

[1] MACKAY MEM HOSP, DEPT PEDIAT, TAIPEI, TAIWAN

[2] UNIV TOKYO, DEPT TRANSFUS MED & IMMUNOHEMATOL, TOKYO, JAPAN

来源：

VOX SANGUINIS | 1995年 / 69卷 / 04期

关键词：

D O I：

10.1111/j.1423-0410.1995.tb00369.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report on two siblings who developed severe neonatal alloimmune thrombocytopenia (NAIT) due to an alloantibody against a labile component or components of the HPA-3a (Bak(a)) antigen. The antibody reacted only with fresh, unfixed platelets by the solid-phase red cell adherence test, immunofluorescence test and mixed passive haemagglutination test, In the latter method: weakly fixed platelets also gave a weak positive reaction, Monoclonal-antibody-specific immobilization of platelet antigens and immunoblotting tests gave negative results, Our findings may possibly help to explain why in some cases of NAIT no platelet-specific antibody is demonstrable in tests with fixed or solubilized platelets,

引用

页码：336 / 340

页数：5

共 16 条

[1] ELECTRON MICROSCOPICAL OBSERVATIONS ON SURFACE COATING OF HUMAN BLOOD PLATELETS [J].