KINETICS AND THERMODYNAMICS OF THE AUTOXIDATION OF REDUCED FLAVIN MONONUCLEOTIDE (FMN)

被引：8

作者：

LIND, J

MERENYI, G

机构：

[1] ROYAL INST TECHNOL,DEPT NUCL CHEM,S-10044 STOCKHOLM 70,SWEDEN

[2] ROYAL INST TECHNOL,DEPT PHYS CHEM,S-10044 STOCKHOLM 70,SWEDEN

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1990年 / 51卷 / 01期

关键词：

D O I：

10.1111/j.1751-1097.1990.tb01679.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— Pulse radiolysis of flavin mononucleotide (FMN) solutions produce flavin semiquinone radicals. The equilibrium constant of radical formation was determined in the pH range2–7 as a function of flavin concentration. Several complex constants as well as the kinetics of equilibration were measured in this pH regime. The rate constant of the autoxidation of the free flavin mononucleotide semiquinone radical was determined to be (1 ± 0.5) × 104M−1 s−1. It is shown that between pH 2 and 7 the direct reaction of the dihydroflavin with oxygen is negligibly slow compared to the rate of autocatalysis. The autoxidation of dihydroflavin is discussed in relation to electron transfer theory. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：21 / 27

页数：7

共 28 条

[1]

Anderson R. F., 1984, FLAVINS FLAVOPROTEIN, P57

[2] ENERGETICS OF THE ONE-ELECTRON REDUCTION STEPS OF RIBOFLAVIN, FMN AND FAD TO THEIR FULLY REDUCED FORMS [J].