REGRESSION MODELING OF HLA HAPLOTYPE SHARING IN AFFECTED SIBLINGS

被引：2

作者：

DARLINGTON, GA ^{[1
]}

FAREWELL, VT ^{[1
]}

机构：

[1] UNIV WATERLOO,DEPT STAT & ACTUARIAL SCI,WATERLOO N2L 3G1,ONTARIO,CANADA

来源：

BIOMETRICS | 1990年 / 46卷 / 02期

关键词：

D O I：

10.2307/2531447

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A link between the HLA system and disease susceptibility can be assessed through the observation of families containing two or more affected siblings. Departures from Mendelian inheritance of the parental haplotypes among the affected siblings are an indication of such a relationship. Other to examining the degree of haplotype sharing and the effect of other variables of interest on observed sharing is presented and two examples analyzed.

引用

页码：427 / 434

页数：8

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