THE DELETERIOUS EFFECT OF BUTHIONINE SULFOXIMINE, A GLUTATHIONE-DEPLETING AGENT, ON THE CISPLATIN TOXICITY IN MICE

Pretreatment of buthionine sulfoximine (500 mg/kg, i.p., BSO), a potent glutathione-depleting agent, markedly increased the lethality and nephrotoxicity of cisplatin. These results suggest That a reactive electrophilic intermediate may be involved in the mechanism of cisplatin nephrotoxicity and moreover, that renal glutathione may play a protective role against cisplatin-induced nephrotoxicity. © 1990, The Japanese Pharmacological Society. All rights reserved.