MALE DEVELOPMENT OF CHROMOSOMALLY FEMALE MICE TRANSGENIC FOR SRY

被引：1744

作者：

KOOPMAN, P

GUBBAY, J

VIVIAN, N

GOODFELLOW, P

LOVELLBADGE, R

机构：

[1] NATL INST MED RES,MRC,EUKARYOT MOLEC GENET LAB,LONDON NW7 1AA,ENGLAND

[2] IMPERIAL CANC RES FUND,HUMAN MOLEC GENET LAB,LONDON WC2A 3PX,ENGLAND

来源：

NATURE | 1991年 / 351卷 / 6322期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/351117a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.

引用

页码：117 / 121

页数：5

共 42 条

[1] ZFA IS AN EXPRESSED RETROPOSON DERIVED FROM AN ALTERNATIVE TRANSCRIPT OF THE ZFX GENE [J].