EFFECT OF MELOTHRIA-MADERASPATANA ON CARBON TETRACHLORIDE-INDUCED CHANGES IN RAT HEPATIC-MICROSOMAL DRUG-METABOLIZING ENZYME-ACTIVITY

被引：18

作者：

JAYATILAKA, KAPW

THABREW, MI

PERERA, DJB

机构：

[1] UNIV RUHUNA,FAC MED,DEPT BIOCHEM,GALLE,SRI LANKA

[2] UNIV RUHUNA,FAC MED,DEPT PATHOL,GALLE,SRI LANKA

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1990年 / 30卷 / 01期

关键词：

D O I：

10.1016/0378-8741(90)90020-T

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Treatment with an aqueous extract of the aerial parts of Melothria maderaspatana, before or after CCl4 administration in rats markedly decreased CCl4-mediated reductions in aniline hydroxylase and p-aminopyrine N-demethylase activities. Phenobarbital-induced sleeping time in rats and kinetic enzyme studies showed that the effect of the plant was neither due to an induction of the drug metabolizing enzymes nor due to an alteration in the Km values of the enzymes. © 1990.

引用

页码：97 / 105

页数：9

共 19 条

[1]

THE INVOLVEMENT OF IRON AND LIPID-PEROXIDATION IN THE PATHOGENESIS OF HCB INDUCED PORPHYRIA [J].