GLOBAL AND LOCAL METRIC GEOMETRY OF LIGAND-BINDING THERMODYNAMICS

被引：6

作者：

DICERA, E ^{[1
]}

WYMAN, J ^{[1
]}

机构：

[1] UNIV COLORADO,DEPT CHEM & BIOCHEM,BOULDER,CO 80309

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 08期

关键词：

LINKAGE; EQUILIBRIUM; MACROMOLECULE;

D O I：

10.1073/pnas.88.8.3494

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An abstract metric representation of ligand binding thermodynamics reveals the basic connections between the classical thermodynamic theory of binding and linkage [Wyman, J. (1964) Adv. Protein Chem. 19, 223-286] and its site-specific formulation [Di Cera, E. (1990) Biophys. Chem. 37, 147-164]. These two approaches are limit cases of a general metric formulation of binding and linkage that also includes a number of intermediate "mixed" representations.

引用

页码：3494 / 3497

页数：4

共 9 条

[1] THERMODYNAMICS OF LOCAL LINKAGE EFFECTS - CONTRACTED PARTITION-FUNCTIONS AND THE ANALYSIS OF SITE-SPECIFIC ENERGETICS [J].