FACILE PREPARATION OF 3'-OLIGONUCLEOTIDE-PEPTIDE CONJUGATES

被引：55

作者：

JUBY, CD ^{[1
]}

RICHARDSON, CD ^{[1
]}

BROUSSEAU, R ^{[1
]}

机构：

[1] NATL RES COUNCIL CANADA,BIOTECHNOL RES INST,GENET ENGN SECT,MONTREAL H4P 2R2,QUEBEC,CANADA

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 07期

关键词：

D O I：

10.1016/S0040-4039(00)92110-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The solid phase synthesis of 3' deoxyoligonucleotide (17 mer)-peptide conjugates is described. The oligonucleotide is complementary to the template strand of the measles virus in the region of the nucleocapsid protein on the 60 nucleotide leader RNA. The conjugates were synthesized on teflon support using a combination of solid phase FMOC peptide chemistry and phosphoramidite chemistry linked by a branched modifier.

引用

页码：879 / 882

页数：4

共 12 条

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