REPETITIVE CERULEIN-INDUCED PANCREATITIS AND PANCREATIC FIBROSIS IN THE RAT

被引：45

作者：

ELSASSER, HP

HAAKE, T

GRIMMIG, M

ADLER, G

KERN, HF

机构：

[1] Department of Anatomy and Cell Biology, University of Marburg, Marbug

[2] Department of Internal Medicine, University of Marburg, Marbug

来源：

PANCREAS | 1992年 / 7卷 / 03期

关键词：

CERULEIN; FIBROSIS; PANCREATITIS;

D O I：

10.1097/00006676-199205000-00017

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The effect of repetitive inductions of pancreatitis by supramaximal doses of cerulein on pancreatic morphology and collagen content was studied in the rat. Pancreatitis was induced nine times at intervals of about 20 days; 3 days after the last injection of cerulein, pancreatitis was still observed, as indicated by pancreatic weight loss, increase of protein-bound hydroxyproline content, acinar-cell destruction, cellular infiltration, and deposition of collagen fibers. However, 6 weeks later, no differences in the parameters mentioned above were observed between control and cerulein-treated animals. Thus, repetitive induction of pancreatitis in the rat, according to the experimental protocol we used, did not result in pancreatic fibrosis.

引用

页码：385 / 390

页数：6

共 15 条

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