DENOVO BIOSYNTHESIS OF HEME OFFERS A NEW CHEMOTHERAPEUTIC TARGET IN THE HUMAN MALARIAL PARASITE

被引：96

作者：

SUROLIA, N ^{[1
]}

PADMANABAN, G ^{[1
]}

机构：

[1] INDIAN INST SCI, JAWAHARLAL NEHRU CTR ADV SCI RES, BANGALORE 560012, KARNATAKA, INDIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91258-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human malarial parasite, Plasmodium falciparum, has been found to synthesize heme de novo, despite the accumulation of large quantities of polymeric heme derived from the hemoglobin of the red cell host. The parasite δ-aminolevulinate dehydrase level is significantly lower than that of the host and its inhibition by succinylacetone leads to inhibition of parasite protein synthesis and viability. © 1992.

引用

页码：744 / 750

页数：7

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