HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF HYDROCHLOROTHIAZIDE IN SERUM AND URINE

被引：18

作者：

SOLDIN, SJ

HACH, E

POLLARD, A

LOGAN, AG

机构：

[1] Departments of Clinical Biochemistry and Medicine, University of Toronto

[2] Hospital for Sick Children and Mount Sinai Hospital, Toronto, ON

来源：

THERAPEUTIC DRUG MONITORING | 1979年 / 1卷 / 03期

关键词：

High performance liquid chromatography; Hydrochlorothiazide; Serum levels; Urine levels;

D O I：

10.1097/00007691-197901030-00013

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

We report a high performance liquid chromatographic method for the analysis of hydrochlorothiazide in 500 μl of serum or 25 μl of urine. The between-day precision of the analysis (CV 5.0-7.0%) is acceptable, as is the recovery of hydrochlorothiazide (90-96%) and trichloromethiazide (96%) added to serum. No drug or drug metabolite interferences have been noted. The method represents a considerable improvement over existing techniques described in the literature. © 1979 Raven Press, New York.

引用

页码：399 / 408

页数：10

共 12 条

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