MICRODIALYSIS IMPLEMENTED IN THE DESIGN OF A SYSTEM FOR CONTINUOUS GLUCOSE MONITORING

被引:11
作者
LAURELL, T
机构
[1] Department of Electrical Measurements, Lund Institute of Technology, Lund University, S-221 00 Lund
关键词
D O I
10.1016/0925-4005(93)85392-N
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A system for continuous glucose measurements has been developed. The monitoring system is based on glucose withdrawal from the sample site via a microdialysis fibre. By perfusing the microdialysis fibre with a saline solution, the glucose variations around the fibre can also be observed in the perfusion liquid exiting the fibre. The perfusion liquid is passed on to a glucose sensor where the readout of the glucose concentration is performed. A brief description of the design of the microdialysis probe and the glucose sensor is presented. The system is calibrated in vitro for two different flow rates and displays a linear calibration plot within 0-3.5 mmol at 12 mul/min and 0-7 mmol at 25 mul/min. By inserting the microdialysis probe subcutaneously, a continuous in vivo monitoring sequence has been performed and compared with the actual blood glucose values of the patient.
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页码:323 / 326
页数:4
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