STRUCTURAL AND FUNCTIONAL-RELATIONSHIPS OF HETEROTRIMERIC G-PROTEINS

被引:139
作者
RENSDOMIANO, S [1 ]
HAMM, HE [1 ]
机构
[1] UNIV ILLINOIS,COLL MED,DEPT PHYSIOL & BIOPHYS,CHICAGO,IL 60612
关键词
SIGNAL TRANSDUCTION; GTPASE; RECEPTOR; EFFECTOR;
D O I
10.1096/fasebj.9.11.7649405
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Heterotrimeric GTP-binding proteins (G-proteins) are a critical component of signal transduction pathways that carry information received at the cell surface to the appropriate cellular effector system, ultimately achieving a specific cellular response. Heterotrimeric G-proteins consist of an alpha-subunit, which contains the guanine nucleotide binding site and intrinsic GTPase activity, and an inseparable beta gamma-subunit complex. G-proteins act to define the specificity by which a receptor regulates a particular intracellular signaling system, as well as to regulate the duration of the signal. A great deal of structural and functional insight into how G-protein-mediated signal transduction occurs has recently been achieved. This review will discuss the structural features of G-proteins, as well as detail the mechanism by which G-proteins interact with receptors and effectors.
引用
收藏
页码:1059 / 1066
页数:8
相关论文
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