PROTEOLYTIC STUDIES OF HOMOLOGOUS PEPTIDE AND N-SUBSTITUTED GLYCINE PEPTOID OLIGOMERS

被引：287

作者：

MILLER, SM ^{[1
]}

SIMON, RJ ^{[1
]}

NG, S ^{[1
]}

ZUCKERMANN, RN ^{[1
]}

KERR, JM ^{[1
]}

MOOS, WH ^{[1
]}

机构：

[1] CHIRON CORP, EMERYVILLE, CA 94608 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(01)80691-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Homologous L-amino acid, D-amino acid, and parallel and anti-parallel (retro) sequence N-substituted glycine peptide and peptoid oligomers were prepared and incubated with proteases from each major class. The L-amino acid containing peptides were readily cleaved by the appropriate enzymes, while equivalent D-amino acid containing and N-substituted glycine containing oligomers were essentially untouched.

引用

页码：2657 / 2662

页数：6

共 20 条

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