PARACETAMOL (ACETAMINOPHEN) POISONING

被引：157

作者：

THOMAS, SHL

机构：

[1] Wolfson Department of Clinical Pharmacology, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 7RU, Claremont Place

来源：

PHARMACOLOGY & THERAPEUTICS | 1993年 / 60卷 / 01期

关键词：

PARACETAMOL; ACETAMINOPHEN; POISONING; N-ACETYL CYSTEINE; METHIONINE;

D O I：

10.1016/0163-7258(93)90023-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Paracetamol poisoning caused by intentional overdose remains a common cause of morbidity. In this article the mechanism of toxicity and the clinical effects and treatment of poisoning, including specific antidotal therapy, are reviewed. Areas for further research directed at reducing morbidity and mortality from paracetamol poisoning are considered.

引用

页码：91 / 120

页数：30

共 251 条

[1] A ROLE FOR THE GLUTATHIONE-PEROXIDASE REDUCTASE ENZYME-SYSTEM IN THE PROTECTION FROM PARACETAMOL TOXICITY IN ISOLATED MOUSE HEPATOCYTES [J].

ADAMSON, GM ;

HARMAN, AW .

BIOCHEMICAL PHARMACOLOGY, 1989, 38 (19) :3323-3330

[2] AGE-RELATED DIFFERENCES IN SALICYLAMIDE AND ACETAMINOPHEN CONJUGATION IN MAN [J].

ALAM, SN ;

ROBERTS, RJ ;

FISCHER, LJ .

JOURNAL OF PEDIATRICS, 1977, 90 (01) :130-135

[3]

ALBANO E, 1985, MOL PHARMACOL, V28, P306

[4] LIVER TOXICITY AFTER ACETAMINOPHEN INGESTION INADEQUACY OF DOSE ESTIMATE AS AN INDEX OF RISK [J].

AMBRE, J ;

ALEXANDER, M .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1977, 238 (06) :500-501

[5]

BAEG NJ, 1988, AM J GASTROENTEROL, V83, P569

[6] CHRONIC EXCESSIVE ACETAMINOPHEN USE AND LIVER-DAMAGE [J].

BARKER, JD ;

CARLE, DJD ;

ANURAS, S .

ANNALS OF INTERNAL MEDICINE, 1977, 87 (03) :299-301

[7] ADVERSE REACTIONS TO N-ACETYLCYSTEINE [J].

BATEMAN, DN ;

WOODHOUSE, KW ;

RAWLINS, MD .

HUMAN TOXICOLOGY, 1984, 3 (05) :393-398

[8]

BECKETT GJ, 1989, CLIN CHEM, V35, P2186

[9] PREVENTION OF PARACETAMOL-INDUCED LIVER-DAMAGE IN MICE WITH GLUTATHIONE [J].

BENEDETTI, MS ;

LOUIS, A ;

MALNOE, A ;

SCHNEIDER, M ;

LAM, R ;

KREBER, L ;

SMITH, RL .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1975, 27 (08) :629-632

[10] ACETAMINOPHEN IN CHRONIC LIVER-DISEASE [J].

BENSON, GD .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1983, 33 (01) :95-101

← 1 2 3 4 5 6 7 8 9 10 →