INFLUENCE OF CORTISONE ON PROLIFERATION AND METABOLISM OF CONNECTIVE TISSUE IN EXPERIMENTAL CIRRHOSIS OF LIVER

1. In the experimental thioacetamide-cirrhosis after injection of radioactive sulfate the acid mucopolysaccharides of the liver are fractionated by three different methods. - There ist no significant influence of cortisone on the chromatographic elution pattern of the sulfated mucopolysaccharides in the normal as well as in the cirrhotic liver. 2. The influence of a long term treatment with cortisone is studied on the carbon tetrachloride cirrhosis and the thioacetamide cirrhosis. Cortisone cannot inhibit the development of a cirrhosis. The parenchymal cells show a higher degree of damage with an additional cortisone treatment. The mortality of the treated animals is higher. © 1969 Springer-Verlag.