EFFECTS OF CAROTENOIDS ON AFLATOXIN-B1-INDUCED MUTAGENESIS IN SALMONELLA-TYPHIMURIUM TA-100 AND TA-98

被引：38

作者：

HE, YP ^{[1
]}

CAMPBELL, TC ^{[1
]}

机构：

[1] CORNELL UNIV,DIV NUTR SCI,ITHACA,NY 14853

来源：

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 1990年 / 13卷 / 04期

关键词：

D O I：

10.1080/01635589009514066

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effects of 0-carotene, canthaxanthin, and extracts of tomato paste (containing lycopene) and orange juice (containing cryptoxanthin) on aflatoxin B2 (AFB2)-induced mutagenesis in S. typhimurium TA 100 and TA 98 were investigated. Inhibition of mutagenesis was studied during and following completion of AFB 2metabolism (i.e., after the addition of menadione), thereby permitting separate examination of the metabolic activation and phenotypic expression phases. Each experimental carotenoid, except lycopene, inhibited AFB rinduced mutagenesis in both tester strains. Cryptoxanthin was the most potent inhibitor, being at least an order of magnitude more potent than the other carotenoids. Inhibition by B-carotene and canthaxanthin was more prominent during the activation phase, whereas cryptoxanthin was more effective during the subsequent phenotypic expression phase. These inhibitory effects were not dependent on conversion to retinol. (Nutr Cancer 13, 243–253, 1990). © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：243 / 253

页数：11

共 43 条

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