EFFECTS OF ENDOTHELIN-1 ON ISOLATED VASCULAR BEDS FROM NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS

被引：13

作者：

MACLEAN, MR

MCGRATH, JC

机构：

[1] Autonomie Physiology Unit, Institute of Physiology, University of Glasgow, Glasgow

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 190卷 / 1-2期

基金：

英国惠康基金;

关键词：

Endothelin-1; Spontaneously hypertensive rats (SHR); Vascular beds; Vasoconstriction;

D O I：

10.1016/0014-2999(90)94137-M

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Endothelin-1 and noradrenaline induced dose-dependent presser responses in isolated in situ blood perfused mesenteric arterial beds and isolated tail arterial beds of anaesthetised spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). In the tail the sensitivity and maximum to either agonist were the same in SHR and WKY whereas in the mesenteric bed the maximum pressor responses to both agonists were increased in SHR. This effect of endothelin-1 may contribute to the greater increase in blood pressure it induces in anaesthetised SHR compared with WKY. © 1990.

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页码：263 / 267

页数：5

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