ABSENCE OF SELECTION OF HIV-1 VARIANTS INVIVO BASED ON TRANSCRIPTION TRANSACTIVATION DURING PROGRESSION TO AIDS

被引：19

作者：

DELASSUS, S ^{[1
]}

MEYERHANS, A ^{[1
]}

CHEYNIER, R ^{[1
]}

WAINHOBSON, S ^{[1
]}

机构：

[1] INST PASTEUR,RETROVIROL MOLEC LAB,28 RUE DR ROUX,F-75724 PARIS 15,FRANCE

来源：

VIROLOGY | 1992年 / 188卷 / 02期

关键词：

D O I：

10.1016/0042-6822(92)90536-X

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The activity of the human immunodeficiency virus type 1 (HIV-1) transactivation protagonists tat and TAR has been analyzed from sequential primary material. The sequences were amplified from uncultured peripheral blood mononuclear cells. Despite fluctuations within the tat and TAR quasispecies there was no obvious selection for a variant encoding more powerful transactivation components either in vivo or ex vivo, indicating that this system is not exploited during disease progression. The basal levels of the natural promoters were, depending on the cell line, two- to fourfold higher than that of the reference promoter, itself derived from ex vivo adapted HIV-1 Lai. © 1992.

引用

页码：811 / 818

页数：8

共 25 条

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