MEASUREMENT OF GAMMA-AMINOBUTYRIC ACID IN HUMAN CEREBROSPINAL-FLUID - RADIORECEPTOR ASSAY USING (H-3) MUSCIMOL

被引：7

作者：

BARACZKA, K ^{[1
]}

SPERK, G ^{[1
]}

机构：

[1] VIENNA UNIV, INST BIOCHEM PHARMACOL, A-1090 VIENNA, AUSTRIA

来源：

CLINICA CHIMICA ACTA | 1981年 / 109卷 / 01期

关键词：

D O I：

10.1016/0009-8981(81)90139-X

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

A method for the determination of GABA levels in human CSF by modification in the radioreceptor assay utilizing [3H]muscimol as labeled ligand is described. This method was compared with the radioreceptor assay using [3H]GABA as labeled ligand. Although the [3H]muscimol assay was less sensitive than the [3H]GABA method, it was more rapid due to the use of a filtration step instead of the usual, more time-consuming centrifugation of the samples. Samples of CSF of patients with various neurological or psychiatric disturbances were analyzed. There was a satisfactory correlation between the GABA values obtained by the 2 assays.

引用

页码：77 / 82

页数：6

共 12 条

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