DOWN-REGULATION OF BETA-ADRENERGIC RECEPTORS INDUCED BY MITOGEN ACTIVATION OF INTRACELLULAR SIGNALING EVENTS IN LYMPHOCYTES

被引：35

作者：

CAZAUX, CA ^{[1
]}

STERINBORDA, L ^{[1
]}

GORELIK, G ^{[1
]}

CREMASCHI, GA ^{[1
]}

机构：

[1] CONSEJO NACL INVEST CIENT & TECN, CTR ESTUDIOS FARMACOL & BOT, RA-1414 BUENOS AIRES, DF, ARGENTINA

来源：

FEBS LETTERS | 1995年 / 364卷 / 02期

关键词：

BETA-ADRENOCEPTOR; PROLIFERATION; TYROSINE KINASE; PROTEIN KINASE; INTRACELLULAR SIGNALING;

D O I：

10.1016/0014-5793(95)00366-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The expression of beta-adrenergic receptors on murine lymphocytes stimulated with concanavalin A was studied. A decrease in beta-adrenoceptor number on T lymphocytes and a diminished response to specific agonist stimulation at the peak of proliferation was found. The blockade of cell proliferation by tyrosine kinases or protein kinase C inhibitors reversed the decrease in beta-adrenoceptor number. PMA plus ionophore or interleukin-2 but not PMA alone were able to induce beta-adrenoceptor down-regulation accompanying cellular proliferation, These results showed that the intracellular signals triggered during lymphocyte activation are involved in beta-adrenoceptor down-regulation and it would represent the loss of a mechanism that exerts negative neuroimmune control of cellular proliferation.

引用

页码：120 / 124

页数：5

共 31 条

[1] REGULATION OF MITOGEN-STIMULATED HUMAN T-CELL PROLIFERATION, INTERLEUKIN-2 PRODUCTION, AND INTERLEUKIN-2 RECEPTOR EXPRESSION BY PROTEIN-KINASE-C INHIBITOR, H-7 [J].