DIFFERENCES IN SENSITIVITY TO FARNESOL TOXICITY BETWEEN NEOPLASTICALLY-DERIVED AND NON-NEOPLASTICALLY-DERIVED CELLS IN CULTURE

被引：54

作者：

ADANY, I

YAZLOVITSKAYA, EM

HAUG, JS

VOZIYAN, PA

MELNYKOVYCH, G

机构：

[1] UNIV KANSAS,MED CTR,DEPT MICROBIOL MOLEC GENET & IMMUNOL,KANSAS CITY,KS 66103

[2] DEPT VET AFFAIRS MED CTR,RES SERV,KANSAS CITY,MO 64128

来源：

CANCER LETTERS | 1994年 / 79卷 / 02期

关键词：

FARNESOL; TOXICOLOGY; CELL CULTURES;

D O I：

10.1016/0304-3835(94)90257-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Six neoplastically-derived cell lines and three cell lines derived from normal tissues were compared for their sensitivity to isoprenoid irons-trans farnesol. Assays of cell numbers and of protein concentrations per culture revealed greater sensitivity of neoplastic cells than of the normal cells. Similar differences were obtained from the comparison of incorporation of [methyl-H-3]choline into cellular lipids, with neoplastic cells showing greater inhibition than normal cells.

引用

页码：175 / 179

页数：5

共 15 条

[1] POLY-UNSATURATED FATTY ACID-INDUCED CYTO-TOXICITY AGAINST TUMOR-CELLS AND ITS RELATIONSHIP TO LIPID-PEROXIDATION
BEGIN, ME
ELLS, G
HORROBIN, DF
[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1988, 80 (03) : 188 - 194
[2] CHABOT MC, 1989, CANCER RES, V49, P4441
[3] DAUD SS, 1992, ANTI-CANCER DRUG, V3, P443
[4] THE EFFECT OF CULTURE-MEDIUM COMPOSITION ON ETHER LIPID CYTOTOXIC ACTIVITY
DIOMEDE, L
PIOVANI, B
MODEST, EJ
SALMONA, M
[J]. LIPIDS, 1993, 28 (03) : 189 - 192
[5] INDUCTION OF APOPTOSIS IN HUMAN LEUKEMIC-CELLS BY THE ETHER LIPID 1-OCTADECYL-2-METHYL-RAC-GLYCERO-3-PHOSPHOCHOLINE - A POSSIBLE BASIS FOR ITS SELECTIVE ACTION
DIOMEDE, L
COLOTTA, F
PIOVANI, B
RE, F
MODEST, EJ
SALMONA, M
[J]. INTERNATIONAL JOURNAL OF CANCER, 1993, 53 (01) : 124 - 130
[6] AN IMPROVED METHOD TO DETERMINE CELL VIABILITY BY SIMULTANEOUS STAINING WITH FLUORESCEIN DIACETATE PROPIDIUM IODIDE
JONES, KH
SENFT, JA
[J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1985, 33 (01) : 77 - 79
[7] GROWTH-INHIBITION OF LEUKEMIA-CELL LINE CEM-C1 BY FARNESOL - EFFECTS OF PHOSPHATIDYLCHOLINE AND DIACYLGLYCEROL
MELNYKOVYCH, G
HAUG, JS
GOLDNER, CM
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 186 (01) : 543 - 548
[8] MODOLELL M, 1979, CANCER RES, V39, P4681
[9] EARLY AND SELECTIVE INDUCTION OF APOPTOSIS IN HUMAN LEUKEMIC-CELLS BY THE ALKYL-LYSOPHOSPHOLIPID ET-18-OCH3
MOLLINEDO, F
MARTINEZDALMAU, R
MODOLELL, M
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 192 (02) : 603 - 609
[10] AGENTS THAT ACTIVATE PROTEIN-KINASE-C RESCUE SHEEP ILEAL PEYER PATCH B-CELLS FROM APOPTOSIS
MOTYKA, B
GRIEBEL, PJ
REYNOLDS, JD
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (06) : 1314 - 1321

← 1 2 →