ANALYSIS OF MAB REACTIVE WITH THE PORCINE SWC1

被引：23

作者：

SAALMULLER, A

AASTED, B

CANALS, A

DOMINGUEZ, J

GOLDMAN, T

LUNNEY, JK

PAULY, T

PESCOVITZ, MD

POSPISIL, R

SALMON, H

SINKORA, J

SUMMERFIELD, A

VALPOTIC, I

VIZCAINO, JS

ZUCKERMANN, F

机构：

[1] ROYAL VET & AGR UNIV,DEPT VET VIROL & IMMUNOL,DK-1870 FREDERIKSBERG C,DENMARK

[2] INIA,DEPT SANIDAD ANIM,E-28012 MADRID,SPAIN

[3] USDA ARS,HELMINTH DIS LAB,BELTSVILLE,MD 20705

[4] INDIANA UNIV,DEPT SURG & MICROBIOL IMMUNOL,INDIANAPOLIS,IN 46202

[5] ACAD SCI CZECH REPUBL,INST MICROBIOL,DEPT IMMUNOL,CR-14220 PRAGUE,CZECH REPUBLIC

[6] INRA,IMMUNOL LAB,F-37380 MONNAIE,FRANCE

[7] UNIV ZAGREB,FAC VET,DEPT BIOL,ZAGREB 41000,CROATIA

[8] UNIV ILLINOIS,COLL VET MED,DEPT VET PATHOBIOL,URBANA,IL 61801

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 1994年 / 43卷 / 1-3期

关键词：

D O I：

10.1016/0165-2427(94)90145-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Among 54 mAb determined to be reactive with porcine T lymphocytes and/or activation antigens, eight mAb (workshop Nos. 005, 031, 080, 091, 092, 093, 094 and 110) derived from different laboratories grouped together in the T11 cluster and were ordered into the SWC1. One mAb (No. 111) which belong also to this group was lost during the workshop. The SWC1 antigen is a molecule expressed on the majority of leukocytes, resting T lymphocytes, monocytes and granulocytes, but not on B lymphocytes. On T Iymphocytes it is down-regulated after activation. The molecular mass of the antigen is unknown. Epitope analyses revealed that seven out of the nine mAb recognized similar epitopes on the SWC1 molecule.

引用

页码：255 / 258

页数：4