AN NMDA-MEDIATED COMPONENT OF EXCITATORY SYNAPTIC INPUT TO DENTATE GRANULE CELLS IN EPILEPTIC HUMAN HIPPOCAMPUS STUDIED INVITRO

被引：49

作者：

URBAN, L

AITKEN, PG

FRIEDMAN, A

SOMJEN, GG

机构：

[1] DUKE UNIV,MED CTR,DEPT CELL BIOL,BOX 3709,DURHAM,NC 27710

[2] DUKE UNIV,MED CTR,DIV NEUROSURG,DURHAM,NC 27710

[3] DUKE UNIV,MED CTR,DEPT NEUROBIOL,DURHAM,NC 27710

来源：

BRAIN RESEARCH | 1990年 / 515卷 / 1-2期

关键词：

Dentate gyrus; Epilepsy; Hippocampus; Human; N-Methyl-d-aspartate;

D O I：

10.1016/0006-8993(90)90615-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recordings were made from human hippocampal tissue surgically removed for treatment of epilepsy. In 70% of cases, an N-methyl-d-asparte (NMDA) receptor-mediated component was present in excitatory synaptic input to gyrus dentatus. NMDA receptors are normally present, but do not participate in low-frequency synaptic transmission, in this region of the mammalian brain. These findings suggest that recruitment of normally dormant excitatory amino acid receptors may be a feature of the epileptic brain. © 1990.

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页码：319 / 322

页数：4

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