A NOVEL METHOD FOR THE SPECIFIC GLYCOSYLATION OF PROTEINS

被引：71

作者：

DAVIS, NJ ^{[1
]}

FLITSCH, SL ^{[1
]}

机构：

[1] DYSON PERRINS LAB,S PARKS RD,OXFORD OX1 3QY,ENGLAND

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 46期

关键词：

GLYCOSYLATION; CYSTEINE SIDE-CHAINS; IODOACETAMIDE; GLUTATHIONE; BOVINE SERUM ALBUMIN;

D O I：

10.1016/S0040-4039(00)93605-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The N-acetyl-glucosamine derivative 1 was synthesised and reacted with peptides and proteins containing cysteine residues. Analysis of products by nmr and mass spectroscopy showed that the thiol groups of cysteine were selectively glycosylated via a new sugar-protein linkage (as in 2).

引用

页码：6793 / 6796

页数：4

共 14 条

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